Two patients with occult solitary myeloma had a progressive, painful sensorimotor peripheral neuropathy that improved after localized radiotherapy to the myeloma site. The patients have had remissions of the neuropathy and myeloma for 10 and 11/2 years.
Review of 46 cases of myeloma and neuropathy indicates that a progressive, painful sensorimotor neuropathy in a middle-aged man suggests a myeloma neuropathy. The neuropathy preceded detection of the myeloma in 80% of the cases. The myeloma was solitary 24% of the time. Radiotherapy, particularly to a solitary myeloma, offered the greatest chance for remission of the neuropathy.
Davis LE, Drachman DB. Myeloma Neuropathy: Successful Treatment of Two Patients and Review of Cases. Arch Neurol. 1972;27(6):507–511. doi:10.1001/archneur.1972.00490180043010
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