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December 1972

Catecholamines and Indoleamines in Patients With Duchenne Muscular Dystrophy

Author Affiliations

Bethesda, Md
From the Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, and the Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Md.

Arch Neurol. 1972;27(6):518-520. doi:10.1001/archneur.1972.00490180054012

Several studies have raised the question of abnormal biogenic amine metabolism in Duchenne muscular dystrophy (DMD). A small group of DMD patients and controls were screened for abnormalities in systemic biogenic amine metabolism in a carefully controlled clinical environment The mean 24-hour urinary excretion levels of norepinephrine, epinephrine, and 5-hydroxyindoleacetic acid (5-HIAA) were identical in the group of DMD patients compared to their normal sibling controls. In the cerebrospinal fluid (CSF), 5-HIAA and homovanillic acid (HVA) levels were similar in DMD patients and controls, and no 5-hydroxytryptamine (5-HT) was detected in the CSF of either group. This study suggests that the characteristic lesions of DMD do not result from a simple excess of circulating amines.

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