Absolute regional cerebral blood volume (rCBV) was measured in vivo by the method of stimulated x-ray fluorescence of an iodinated contrast material. This is a noninvasive intravenous technique which allows the study of a volume of the brain approximately 1 cc in size. Initially, the method was validated in dogs and monkeys by demonstrating a good correlation between rCBV values obtained by fluorescence and rCBV values obtained with red blood cells labeled with radioactive chromium (51 Cr) in frozen, excised brain samples. Absolute regional cerebral blood volume was then measured in normal human volunteers, giving an average value of 3.20 cc/100 gm tissue.
Grubb RL, Phelps ME, Ter-Pogossian MM. Regional Cerebral Blood Volume in Humans: X-Ray Fluorescence Studies. Arch Neurol. 1973;28(1):38–44. doi:10.1001/archneur.1973.00490190056006
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