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March 1973

Brain Metabolism During Hypoglycemia: Effect of Insulin on Regional Central Nervous System Glucose and Energy Reserves in Mice

Author Affiliations

St. Louis
From the Edward Mallinckrodt Department of Pharmacology, and the Department of Neurology, Washington University School of Medicine, St. Louis.

Arch Neurol. 1973;28(3):173-177. doi:10.1001/archneur.1973.00490210053006

Adenosine triphosphate (ATP), phosphocreatine, glucose levels, and metabolic rates were measured in several regions of the central nervous system (CNS) of normal and hypoglycemic (insulin) mice. Following insulin treatment, there was a progressive deterioration of neurological function, a uniform, marked decrease of glucose reserves, and a uniform depression of metabolic rate throughout the CNS; however, ATP and phosphocreatine levels were unaltered. These results indicate that the functional encephalopathy resulting from hypoglycemia is not due to a lack of chemical energy. Also, the present results indicate that the clinically apparent depression of neural function in progressively descending levels of the CNS during hypoglycemia is not a result of a depletion of glucose reserves or depression of metabolic rate more rapidly in the rostral portions of the CNS than in the more caudal portions.

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