Carnitine was identified as a constituent of normal human serum by reaction with a specific enzyme and by thin-layer chromatography. A spectrophotometric enzymatic assay was adapted for use with human serum, based upon the liberation of coenzyme A from acetylcoenzyme A in the presence of carnitine and carnitine acetyltransferase. Normal human serum contains 2.3μmols to 7.0μmols/100ml. Serum content increased to 33.4μmols/100 ml during attacks of myoglobinuria but was not increased in patients with Duchenne dystrophy, liver disease, uremia, or acute myocardial infarction.
DiMauro S, Scott C, Penn AS, Rowland LP. Serum Carnitine: An Index of Muscle Destruction in Man. Arch Neurol. 1973;28(3):186–190. doi:10.1001/archneur.1973.00490210066009
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