In the tadpole and during the early metamorphotic stage of Rana temporaria, sarcoplasmic masses occur throughout the musculature.
During the metamorphotic stage of Xenopus laevis, denervation features occur with (in lesser degree) sarcoplasmic masses or granular degeneration.
Autoradiographic study in X laevis has revealed a blood-brain barrier in the tadpole to levothyroxine l 125, liothyronine I 125, sodium iodide 125, liothyronine 1131, and levothyroxine I 131. This barrier persists in the tail segment of the spinal cord during metamorphosis, but disappears for the brain and the trunk level of the cord. Similar observations were made with levothyroxine l 131 in R temporaria.
Jager WA, de Jong JMBV, van der Schoot JB. Muscle and Central Nervous System Metamorphosis: Histology and Autoradiography. Arch Neurol. 1973;28(3):191–194. doi:10.1001/archneur.1973.00490210071010
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