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April 1973

Guillain-Barré Syndrome: Increased Lymphoproliferative Potential

Author Affiliations

New York
From the Department of Neurology and the Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York.

Arch Neurol. 1973;28(4):215-218. doi:10.1001/archneur.1973.00490220023001

Peripheral white blood cells (WBC) from normal persons, patients with Guillain-BarréSyndrome (GBS), and persons with a variety of other neurological diseases were maintained in tissue culture. The WBC from patients with GBS demonstrated a greatly increased tendency to become continuous self-proliferating lines of lymphoblastoid cells. Cell lines from both normal subjects and patients were examined by light and electron microscopy. Herpes-like viral particles were found in both varieties of lines. Epstein-Barr virus antigen was demonstrated in most of the cell lines. Animal inoculations of the cells failed to produce any clinical or morphological alterations in the recipients.

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