Neuroblastoma and transformed glial cell cultures vary from nonpermissive to completely permissive for infectious herpes simplex virus (HSV) production. Electron microscopy shows that (1) the amount of infectious virus produced by a cell is related to the extent to which the cell nuclear membrane becomes altered by the infection, and (2) in one transformed glial line which makes no infectious virus (the C-6 line) the nuclear membrane is not structurally altered at all and only incomplete virus particles are made. Implantation of C-6 cells into hamsters results in the formation of an astrocytoma; implantation of HSV-infected C-6 cells initiates a chronic HSV infection in the animal.
These studies are significant because they suggest a mode of latent HSV infection, especially as it relates to the nervous system.
Schwartz J, Elizan TS. Chronic Herpes Simplex Virus Infection: Initiation in Hamsters Upon Implantation of Infected Nonpermissive Glial Cells. Arch Neurol. 1973;28(4):224–230. doi:10.1001/archneur.1973.00490220032003
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