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April 1973

Brain Scans in Autopsy Proved Cases of Intracerebral Hemorrhage

Arch Neurol. 1973;28(4):270-271. doi:10.1001/archneur.1973.00490220078012

Contrary to the generally held belief that intracerebral hemorrhage and hemorrhagic infarcts frequently result in abnormal brain scans with sodium pertechnetate Tc 99m, the present study shows the 99mTc brain scan to be positive in only one out of the nine patients with an autopsy proved diagnosis of an intracerebral hemorrhage.

The reasons for the discrepant findings may be as follows: (1) the short time interval between the injection of radionuclide and the commencement of brain scans (less than an hour in most of the patients); (2) brain scanning done too early in four out of nine patients after the onset of symptoms (two days); and (3) finally, the possible difference in the biological behavior of chlormerodrin Hg 203 (Neohydrin-203), pentetic acid (DTPA) labeled with radioactive copper (64Cu), sodium arsenate As 74, and 99mTc.