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April 1973

Elevated Cerebrospinal Fluid Vaccinia Antibodies in Multiple Sclerosis

Author Affiliations

Denver; Los Angeles
From the Department of Pediatrics, University of Colorado Medical Center, Denver (Drs. Kempe, Takabayashi, Miyamoto, and McIntosh); and the departments of neurology (Dr. Tourtellotte) and pediatrics (Dr. Adams), University of California School of Medicine, Los Angeles.

Arch Neurol. 1973;28(4):278-279. doi:10.1001/archneur.1973.00490220086016

Vaccinia virus neutralizing antibodies were measured in the cerebrospinal fluid (CSF) of 187 patients with multiple sclerosis, 87 patients with other neurologic diseases, and 30 normal controls. Detectable antivaccinia antibody was present in the CSF of 30% of the first group, 3% of the second, and none of the third. These findings may have significance in the search for a causal agent in multiple sclerosis.