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April 1973

Experimental Models of Epilepsy: A Manual for the Laboratory Worker.

Arch Neurol. 1973;28(4):284. doi:10.1001/archneur.1973.00490220092020

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This book is something of a landmark, since for the first time it provides a comprehensive description of nearly all major animal models used in experimental epilepsy. Each model is discussed by an investigator who has made major contributions to the field. Descriptions usually provide sufficient technical details to enable a young investigator to reproduce the model under consideration. More important perhaps, the potential strengths and limitations of each method are discussed in detail, often providing information not available anywhere in written form. This book constitutes a Homeric jump from the oral tradition which has been a formidable barrier for new investigators in the field. Many chapters are outstanding, and nearly all have excellent bibliographies. The discussion of topical convulsants, with its meticulous attention to technical pitfalls; that of derangements of extracellular ionic environment; and those of photogenic or audiogenic seizures are examples of clarity and thoroughness. My criticisms are

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