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May 1973

Myelin in Multiple Sclerosis: Composition of Myelin From Normal-Appearing White Matter

Author Affiliations

Philadelphia; Tokyo; Philadelphia; Los Angeles; Philadelphia
From the Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (Drs. Suzuki and Eto, and Mrs. Gonatas); Department of Pediatrics, University of Tokyo, Faculty of Medicine (Dr. Kamoshita); and V. A. Wadsworth Hospital Center, and Department of Neurology, University of California School of Medicine, Los Angeles (Dr. Tourtellotte). Dr. Suzuki is now with the Saul R. Korey Department of Neurology, and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY; and Dt. Eto is with the Department of Pediatrics, University of Bern, Switzerland.

Arch Neurol. 1973;28(5):293-297. doi:10.1001/archneur.1973.00490230029002

Myelin was isolated from white matter of five normal control brains and from normalappearing white matter of five patients with multiple sclerosis. There was statistically significant reduction of 25% to 30% in yield of myelin from abnormal brains, due probably to inadvertent inclusion of small lesions. No abnormalities were found in distribution of major constituents—chloroform-methanol soluble and insoluble proteins and total lipid. Analysis of individual lipids, and fatty acid composition of sphingolipids likewise did not show any differences between control and multiple sclerosis myelin. Contrary to a previous report, myelin isolated from normal-appearing white matter of multiple sclerosis brains contained normal amounts of myelin basic protein. Chemical composition of the myelin sheath in normal-appearing white matter of multiple sclerosis patients is, therefore, completely normal, at least for analytical factors examined.

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