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May 1973

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

Author Affiliations

From the Department of Neurology, Johns Hopkins School of Medicine, Baltimore.

Arch Neurol. 1973;28(5):298-303. doi:10.1001/archneur.1973.00490230034003

Demyelinative lesions were produced in mice by inoculation of JHM virus, a neurotropic strain of mouse hepatitis virus. The production of these lesions was dependent on dosage of virus, age of mice, and route of inoculation. In animals with demyelination, fluorescent antibody staining showed viral antigen was most prominent in the cells of the white matter. No immunopathologic mechanism for demyelination was apparent. No fixation of immunoglobulins in the lesions was seen, nor did immunosuppression with cyclophosphamide prevent demyelination. Focal hepatitis, usually a concomitant finding with white-matter disease, could be prevented without altering the demyelinative lesions. Demyelination in JHM virus-infected mice appeared to be the direct result of infection of glial cells of the white matter.