Cerebral blood flow (CBF) measured by the xenon Xe 133 clearance method and cerebral metabolism was studied in 11 pentobarbital anesthetized, paralyzed, and ventilated patients during electroconvulsive therapy (ECT). Cerebral blood flow, oxygen, and glucose uptake doubled during seizures. Jugular venous Pco2 and Po2 both increased about 10 mm Hg during seizures, while the arterial gas tensions remained virtually unchanged. The jugular venous-arterial lactate difference increased an average of 0.08 millimol/liter one minute after ECT. The respiratory quotient (RQ) increased an average of 0.95 to 1.29 during seizures. The data suggest production of fixed acid (lactic acid) within the brain during seizures, even when arterial hypoxemia was avoided.
Brodersen P, Paulson OB, Bolwig TG, Rogon ZE, Rafaelsen OJ, Lassen NA. Cerebral Hyperemia in Electrically Induced Epileptic Seizures. Arch Neurol. 1973;28(5):334–338. doi:10.1001/archneur.1973.00490230070010
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