[Skip to Navigation]
May 1973

Cerebral Hyperemia in Electrically Induced Epileptic Seizures

Author Affiliations

From the departments of psychiatry (Dr. Paulson), neurology (Dr. Brodersen), clinical Physiology (Dr. Lassen), and anesthesiology (Dr. Rogon), Bispebjerg Hospital, and the Psychochemistry Institute, Rigshospitalet (Drs. Bolwig and Rafaelsen), Copenhagen.

Arch Neurol. 1973;28(5):334-338. doi:10.1001/archneur.1973.00490230070010

Cerebral blood flow (CBF) measured by the xenon Xe 133 clearance method and cerebral metabolism was studied in 11 pentobarbital anesthetized, paralyzed, and ventilated patients during electroconvulsive therapy (ECT). Cerebral blood flow, oxygen, and glucose uptake doubled during seizures. Jugular venous Pco2 and Po2 both increased about 10 mm Hg during seizures, while the arterial gas tensions remained virtually unchanged. The jugular venous-arterial lactate difference increased an average of 0.08 millimol/liter one minute after ECT. The respiratory quotient (RQ) increased an average of 0.95 to 1.29 during seizures. The data suggest production of fixed acid (lactic acid) within the brain during seizures, even when arterial hypoxemia was avoided.

Add or change institution