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June 1973

Experimental Herpes Simplex Encephalitis: Treatment With Pyrimidine Nucleosides

Author Affiliations

San Francisco
From the Neurology Research Laboratory, Veterans Administration Hospital, and the Department of Neurology, University of California, San Francisco.

Arch Neurol. 1973;28(6):371-375. doi:10.1001/archneur.1973.00490240031003

An experimentally induced herpes simplex virus encephalitis in rabbits was treated with either idoxuridine or cytarabine. The cerebral lesions produced in this model bore histologic and topographic similarities to those seen in humans. Treatment was begun after infection was established in nervous system tissue. In animals treated with idoxuridine there was neither clinical nor histological evidence of a therapeutic effect. Cytarabine initially appeared to inhibit the development of lesions, but the effect was temporary.

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