The mongolian gerbil has an anomalous circle of Willis, lacking a major posterior communicating artery. Fatal cerebral infarction followed unilateral carotid artery ligation in the neck in 60% of the cases studied. This mortality was reduced by large intraperitoneal injections of dexamethasone. Evidence is presented that this reduction in mortality is associated with a significant reduction in cerebral edema in the infarcted hemisphere.
Harrison MJG, Brownbill D, Lewis PD, Russell RWR. Cerebral Edema Following Carotid Artery Ligation in the Gerbil. Arch Neurol. 1973;28(6):389–391. doi:10.1001/archneur.1973.00490240049008
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