[Skip to Content]
[Skip to Content Landing]
June 1973

Cerebral Edema Following Carotid Artery Ligation in the Gerbil

Arch Neurol. 1973;28(6):389-391. doi:10.1001/archneur.1973.00490240049008

The mongolian gerbil has an anomalous circle of Willis, lacking a major posterior communicating artery. Fatal cerebral infarction followed unilateral carotid artery ligation in the neck in 60% of the cases studied. This mortality was reduced by large intraperitoneal injections of dexamethasone. Evidence is presented that this reduction in mortality is associated with a significant reduction in cerebral edema in the infarcted hemisphere.