GM1 and GM2 gangliosidosis were detected in utero by amniocentesis with culture of the amniocytes followed by enzyme assay. Diagnosis was followed by saline-induced abortion. Electron microscopic examination of the spinal cords of aborted midterm fetuses revealed membranous cytoplasmic bodies in the anterior horn cells indicating that morphologic manifestations of both GM1 and GM2 gangliosidosis appear early in development.
Percy AK, McCormick UM, Kaback MM, Herndon RM. Ultrastructure Manifestations of GM1 and GM2 Gangliosidosis in Fetal Tissues. Arch Neurol. 1973;28(6):417–419. doi:10.1001/archneur.1973.00490240077016
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