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June 1973

Ultrastructure Manifestations of GM1 and GM2 Gangliosidosis in Fetal Tissues

Author Affiliations

From the departments of neurology (Drs. Percy, McCormick, and Herndon) and pediatrics (Dr. Kaback), Johns Hopkins University School of Medicine, Baltimore. Dr. Kaback is a Joseph P. Kennedy, Jr. Memorial Foundation research scholar in mental retardation. Dr. Percy is now with the Department of Pediatrics, Charles R. Drew Postgraduate Medical School.

Arch Neurol. 1973;28(6):417-419. doi:10.1001/archneur.1973.00490240077016

GM1 and GM2 gangliosidosis were detected in utero by amniocentesis with culture of the amniocytes followed by enzyme assay. Diagnosis was followed by saline-induced abortion. Electron microscopic examination of the spinal cords of aborted midterm fetuses revealed membranous cytoplasmic bodies in the anterior horn cells indicating that morphologic manifestations of both GM1 and GM2 gangliosidosis appear early in development.

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