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July 1973

Immunologic Mechanisms in Experimental Encephalomyelitis in Nonhuman Primates

Author Affiliations

Boston; Bethesda, Md; Philadelphia; Montreal; Quebec
From the departments of neurology and neuropathology, Boston University School of Medicine and the Boston Veterans Administration Hospital; and the Section on Myelin Chemistry, Laboratory on Cerebral Metabolism, National Institute of Mental Health, Bethesda, Md.

Arch Neurol. 1973;29(1):4-9. doi:10.1001/archneur.1973.00490250022002

Experimental allergic encephalomyelitis was induced in large rhesus monkeys by immunizing them with homologous and heterologous myelin basic proteins in different adjuvants. Two clinically and pathologically different types of disease, ordinary and hyperacute, were produced. In both types cell-mediated hypersensitivity was demonstrated to a variety of myelin basic proteins from different species by in vivo and in vitro techniques. Humoral antibody to homologous myelin basic protein could only be found in the fulminant hyperacute form.

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