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August 1973


Arch Neurol. 1973;29(2):94. doi:10.1001/archneur.1973.00490260038006

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Omission of Lines.—In the article, "Studies in Metachromatic Leukodystrophy: XII. Multiple Sulfatase Deficiency," published in the April Archives (28:258-264, 1973), the fifth paragraph in column 2 on page 263 contains parts of two paragraphs. The correct paragraphs follow:

Sulfatides as Substrates for the Sulfatase A Deficiency.—  Patients with MSD-MLD are markedly deficient in arylsulfatase A activity.8,14 Normally, this enzyme appears to function as a cerebroside sulfatase, and its activity is chiefly referable to lysosomes. It is plausible to attribute the increase in cerebroside sulfates (sulfatides) to this sulfatase A deficiency.26

GAGS as Substrates for the Sulfatase B Deficiency.—  MSD-MLD patients are also profoundly deficient in arylsulfatase B activity.8,14 Normally, in liver, this acid hydrolase is referable not only to lysosomes but also to mitochondrial and other membranous elements in the cell (Stumpf D, et al, unpublished data).

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