This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Omission of Lines.—In the article, "Studies in Metachromatic Leukodystrophy: XII. Multiple Sulfatase Deficiency," published in the April Archives (28:258-264, 1973), the fifth paragraph in column 2 on page 263 contains parts of two paragraphs. The correct paragraphs follow:
Sulfatides as Substrates for the Sulfatase A Deficiency.—
Patients with MSD-MLD are markedly deficient in arylsulfatase A activity.8,14 Normally, this enzyme appears to function as a cerebroside sulfatase, and its activity is chiefly referable to lysosomes. It is plausible to attribute the increase in cerebroside sulfates (sulfatides) to this sulfatase A deficiency.26
GAGS as Substrates for the Sulfatase B Deficiency.—
MSD-MLD patients are also profoundly deficient in arylsulfatase B activity.8,14 Normally, in liver, this acid hydrolase is referable not only to lysosomes but also to mitochondrial and other membranous elements in the cell (Stumpf D, et al, unpublished data).