Fifteen patients who developed postural hypotension during levodopa therapy for Parkinson's disease were treated with etilefrine hydrochloride in a single-blind study. A placebo-treated group served as control. Fourteen of the 15 etilefrine-treated patients responded favorably. Before treatment, the mean drop in systolic pressure when assuming upright position was 26.3%; after treatment with 15 mg etilefrine daily, the drop was only 4.3%. The mean diastolic pressure drop prior to treatment averaged 14.2%, compared to 1.2% after treatment. Eighty-six percent of symptoms related to postural hypotension were alleviated. No side effects or laboratory abnormalities were encountered.
Miller E, Wiener L, Bloomfield D. Etilefrine in the Treatment of Levodopa-Induced Orthostatic Hypotension. Arch Neurol. 1973;29(2):99–103. doi:10.1001/archneur.1973.00490260043008
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: