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August 1973

Etilefrine in the Treatment of Levodopa-Induced Orthostatic Hypotension

Author Affiliations

Brooklyn, NY
From the Division of Neurology, Department of Medicine, Maimonides Medical Center, Brooklyn, NY.

Arch Neurol. 1973;29(2):99-103. doi:10.1001/archneur.1973.00490260043008

Fifteen patients who developed postural hypotension during levodopa therapy for Parkinson's disease were treated with etilefrine hydrochloride in a single-blind study. A placebo-treated group served as control. Fourteen of the 15 etilefrine-treated patients responded favorably. Before treatment, the mean drop in systolic pressure when assuming upright position was 26.3%; after treatment with 15 mg etilefrine daily, the drop was only 4.3%. The mean diastolic pressure drop prior to treatment averaged 14.2%, compared to 1.2% after treatment. Eighty-six percent of symptoms related to postural hypotension were alleviated. No side effects or laboratory abnormalities were encountered.

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