Three patients with parkinsonism treated with levodopa had abnormal pre-levodopa and stabilization levodopa electroencephalograms with focal sharp and spikewave activity. There were no seizures and no significant EEG changes with levodopa treatment. This suggests that levodopa may not aggravate a preexisting seizure tendency, as suggested by the EEG.
Newman SE, Tucker RP, Kooi KA. Lack of Levodopa Effect on Preexisting Temporal Lobe Focus. Arch Neurol. 1973;29(2):122–123. doi:10.1001/archneur.1973.00490260066014
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