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September 1973

Cerebral Edema: The Effect of Dexamethasone During Brain Maturation in the Rat

Author Affiliations

Göteborg, Sweden
From the Department of Pharmacology, University of Göteborg, Göteborg, Sweden.

Arch Neurol. 1973;29(3):151-157. doi:10.1001/archneur.1973.00490270033004

Brain edema was produced in 5- and 30-day-old rats by the intrathecal infusion of tracer doses of inulin labeled with carbon 14 dissolved in microliter volumes of artificial cerebrospinal fluid. The older animal showed a sustained elevation of spinal fluid pressure in association with a marked resistance to penetration of labeled inulin into the brain stem and cerebellum. In contrast, continuous penetration of the extracellular marker into the edematous brain of the 5-day-old rat was found. Pretreatment with dexamethasone completely prevented abnormal fluid accumulation. Additionally, the access route of inulin 14C to the extracellular space was restored in the older animal, while this influx via the intercellular clefts was only minimally enhanced in the younger animal. An important mechanism of action of dexamethasone may be the prevention of swelling in glia and their processes.