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September 1973

Hexachlorophene Neuropathy

Author Affiliations

From the Department of Neurology, University of Pennsylvania, School of Medicine, and Philadelphia General Hospital, Philadelphia.

Arch Neurol. 1973;29(3):180-182. doi:10.1001/archneur.1973.00490270062009

Rats fed hexachlorophene developed polyneuropathy that was related to dose and time of exposure. Rats fed larger doses had hind-limb wasting and weakness. The motor conduction velocities of sciatic nerves were decreased. The nerves were edematous, and less myelin could be recovered from them. Within a week after discontinuation of hexachlorophene feeding, neuromuscular dysfunction cleared and the nerve conduction velocities returned to normal.

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