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September 1973

Adenosine 3', 5'-Monophosphate in Cerebrospinal Fluid: Effect of Drugs and Neurologic Disease

Author Affiliations

Bethesda, Md
From the Neurology Unit, National Institute of Mental Health, Bethesda, Md. Dr. Cramer is now with the Department of Neurology, University of Freiburg, Freiburg, Germany.

Arch Neurol. 1973;29(3):197-199. doi:10.1001/archneur.1973.00490270079014

Adenosine 3',5'-monophosphate (cyclic AMP) was measured in lumbar spinal fluid of 41 patients with peripheral or central nervous system (CNS) disease. Cyclic AMP levels appeared unrelated to age, sex, or time of day that samples were obtained. Levels in patients with Parkinson's disease did not differ significantly from those in patients with familial or acquired dyskinesias, spinocerebellar disorders, or from those in patients free of CNS disease. Neither acute nor chronic administration of levodopa altered cyclic AMP concentrations. In contrast, probenecid caused a substantial rise in levels of this nucleotide. Results suggest that cyclic AMP efflux from the spinal fluid compartment may be mediated by a probenecid-sensitive transport system and that use of probenecid may provide a means for studying drug or disease effects on the central turnover of cyclic AMP in man.

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