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September 1973

Thoracic Duct Lymphocyte Depletion in Myasthenia Gravis

Author Affiliations

Galveston, Tex
From the Division of Neurology (Drs. Tindall, Peters, and Caverley), and the departments of medicine (Dr. Sarles), and surgery (Dr. Fish), the University of Texas Medical Branch, Galveston.

Arch Neurol. 1973;29(3):202-203. doi:10.1001/archneur.1973.00490270084016

Thoracic duct lymphocyte depletion, a technique that selectively suppresses cellular immune defenses, was performed in a patient with myasthenia gravis. The patient demonstrated a 70% reduction in anticholinesterase medication requirement. These data lend further support to the apparent relationship between myasthenia gravis, the thymus, and cell-mediated immunity and implicate the lymphocyte, or a substance bound to it, as a contributing factor in myasthenia gravis.

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