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October 1973

Anticonvulsive Action of Increased Calcium Concentration in Cerebrospinal Fluid

Author Affiliations

New Haven, Conn
From the Department of Neurology, Yale University School of Medicine, New Haven, Conn.

Arch Neurol. 1973;29(4):245-252. doi:10.1001/archneur.1973.00490280057008

Perfusion of the inferior horn of the lateral ventricle with an artificial cerebrospinal fluid (CSF) containing 3.3 to 6.6 millimolar/liter of calcium (Ca++) has a strong anticonvulsive action in chronic, awake cats. This action was almost equally evident when the dorsal hippocampus was stimulated by any of these agents: repetitive electrical stimulation; increased potassium (K+) in the perfused CSF; infusion of penicillin, pentylenetetrazol, L-glutamate, or a combination of acetylcholine and edrophonium. The assumption is made that increased Ca++ has this wide anticonvulsant property probably by blocking the action of K+.

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