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October 1973

Remyelination in Multiple Sclerosis With Peripheral Type Myelin

Author Affiliations

Bronx, NY
From the Division of Neuropathology, Department of Pathology, Montefiore Hospital and Medical Center, and Albert Einstein College of Medicine, Bronx, NY.

Arch Neurol. 1973;29(4):262-267. doi:10.1001/archneur.1973.00490280074011

Unusually large areas of remyelination occurred in demyelinated plaques within the spinal cord of a patient with longstanding multiple sclerosis (MS). The regenerated myelin was indistinguishable from that of the peripheral nerves by optical and electron microscopy. The myelinforming cells within the spinal cord, morphologically identical to the Schwann cells, could be traced to the spinal nerve roots. At the periphery of the remyelinated zones, astrocytic processes were present adjacent to the regenerated peripheral type myelinated fibers similar to those normally seen in the nerve roots close to the spinal cord. In addition, Rosenthal fibers were frequently seen in such zones. There was no appreciable clinical improvement in this patient attributable to the remyelination. The mechanism of such focal remyelination in this otherwise typical case of MS remains obscure.

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