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November 1973

Transient Global Amnesia Due to Arterial Embolism

Author Affiliations

Columbus, Ohio
From the Division of Neurology, Department of Medicine, Ohio State University, Columbus.

Arch Neurol. 1973;29(5):340-342. doi:10.1001/archneur.1973.00490290080011

Transient global amnesia is a well-recognized clinical entity, but its pathophysiology has remained obscure. Two typical cases with onset during cardiac angiography have been observed in which arterial embolization appears to have been the cause of this syndrome. Both patients had the sudden onset of a profound global recent memory defect with sparing of immediate recall and relative sparing of remote memory except for a variable degree of retrograde amnesia. A detailed neurological examination failed to reveal any additional central nervous system dysfunction at any time during the amnestic episode. Complete recovery occurred except for a persistent amnesia for events occurring during the attack.

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