Transient global amnesia is a well-recognized clinical entity, but its pathophysiology has remained obscure. Two typical cases with onset during cardiac angiography have been observed in which arterial embolization appears to have been the cause of this syndrome. Both patients had the sudden onset of a profound global recent memory defect with sparing of immediate recall and relative sparing of remote memory except for a variable degree of retrograde amnesia. A detailed neurological examination failed to reveal any additional central nervous system dysfunction at any time during the amnestic episode. Complete recovery occurred except for a persistent amnesia for events occurring during the attack.
Shuttleworth EC, Wise GR. Transient Global Amnesia Due to Arterial Embolism. Arch Neurol. 1973;29(5):340–342. doi:10.1001/archneur.1973.00490290080011
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: