The effect of "compression ischemia" on brain mitochondrial activity was examined in 61 rabbits. We found that (1) the respiratory control ratio was significantly decreased only after 30 and 40 minutes of compression ischemia due to a decrease in state 3 and an increase in state 4 respiration; (2) heavy uncoupling of respiration occurred only after 40 minutes of compression ischemia; (3) uncoupler-activated adenosine triphosphatase (ATPase) was not impaired even after 40 minutes of ischemia, but spontaneous ATPase activity increased significantly; (4) secondary deterioration of mitochondrial function after circulatory recovery did not occur even with severe hypercapnia and hypocapnia in the recovery period as long as the cerebral perfusion pressure was maintained.
The findings suggest that alterations in constituents of the cell other than the mitochondria are responsible for irreversible brain damage following brief periods of total cerebral ischemia.
Schutz H, Silverstein PR, Vapalahti M, Bruce DA, Mela L, Langfitt TW. Brain Mitochondrial Function After Ischemia and Hypoxia: I. Ischemia Induced by Increased Intracranial Pressure. Arch Neurol. 1973;29(6):408–416. doi:10.1001/archneur.1973.00490300070009
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.