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January 1974

On the Treatment of Rapid Eye Movement Narcolepsy

Author Affiliations

Stanford, Calif
From the Sleep Disorders Clinic and Laboratory, Stanford University School of Medicine, Stanford, Calif.

Arch Neurol. 1974;30(1):90-93. doi:10.1001/archneur.1974.00490310092014

Fifty patients were diagnosed as having rapid eye movement (REM) narcolepsy by means of polygraphic recordings. The effectiveness of amphetamine and tricyclic antidepressant drugs on the classical symptoms of REM narcolepsy were considered. Side effects developed with each of these medications. Imipramine hydrochloride and clomipramine hydrochloride appear to be effective for cataplexy, sleep paralysis and hypnagogic hallucinations, but there is no effective and harmless treatment for daytime sleep attacks.

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