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January 1974

Creatine Phosphokinase: Increased Activity of the Spinal Fluid in Psychotic Patients

Arch Neurol. 1974;30(1):103-104. doi:10.1001/archneur.1974.00490310105017

Spinal fluid samples from psychotic patients were examined for creatine phosphokinase (CPK). Increased enzyme activity was found in 12 out of 40 patients. Creatine phosphokinase values ranged from 1 to 11 international units (IU)/100 ml; mean, 4 IU ± 3.5 SD.

Patients showing increased CPK values in spinal fluid were those in whom the psychotic state was in the acute phase of evolution. No other clinical correlation could be determined.