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January 1974

Creatine Phosphokinase: Increased Activity of the Spinal Fluid in Psychotic Patients

Author Affiliations

Mexico City
From the Universidad Nacional Autónoma de México, Mexico City. Dr. Vale is now at Clinica Londres, Durango 33, DF, Mexico; Dr. Espejel is now at Hospital Psiquiátrico "Fray Bernardino Alvarez," SSA, Tlalpan 22, DF, Mexico; and Drs. Calcaneo, Ocampo, and Diaz-de-Leon are with Laboratorios Clínicos de Mexico, Durango 50, DF, Mexico.

Arch Neurol. 1974;30(1):103-104. doi:10.1001/archneur.1974.00490310105017

Spinal fluid samples from psychotic patients were examined for creatine phosphokinase (CPK). Increased enzyme activity was found in 12 out of 40 patients. Creatine phosphokinase values ranged from 1 to 11 international units (IU)/100 ml; mean, 4 IU ± 3.5 SD.

Patients showing increased CPK values in spinal fluid were those in whom the psychotic state was in the acute phase of evolution. No other clinical correlation could be determined.

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