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February 1974

Amyotrophic Lateral Sclerosis: Abnormal Cellular Inflammatory Response

Author Affiliations

Olomouc, Czechoslovakia
From the Clinic of Neurology and Institute of Pathology, Palacký University, Olomouc, Czechoslovakia.

Arch Neurol. 1974;30(2):186-187. doi:10.1001/archneur.1974.00490320074013

In ten patients with amyotrophic lateral sclerosis (ALS) and 146 control subjects, the cellular inflammatory response was studied by the "skin window" technique and 24 hours after inflicting the lesion. In all patients with ALS the migration of macrophages into the inflammatory field was retarded, and in three patients the total number of cells was decreased. This alteration could be due to a latent disorder of the autonomic nervous system.

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