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March 1974

Pulmonary Alveolar Proteinosis and Nocardia Brain Abscess: Report of a Case

Author Affiliations

Eloise, Mich; Ann Arbor, Mich; Eloise, Mich
From the Department of Internal Medicine, Wayne County General Hospital, Eloise, Mich (Drs. Supena and Cramer), and the departments of internal medicine (Dr. Karlin) and pathology (Dr. Strate), University of Michigan Medical Center, Ann Arbor.

Arch Neurol. 1974;30(3):266-268. doi:10.1001/archneur.1974.00490330074014

A 33-year-old white man with previously undiagnosed and relatively asymptomatic pulmonary alveolar proteinosis had a Jacksonian seizure. The diagnosis of pulmonary alveolar proteinosis was established by open lung biopsy. A craniotomy was performed, and a Nocardia brain abscess was excised. The patient was treated with sulfonamides and recovered. The intra-alveolar phospholipid that accumulates in this disease tends to become infected by opportunistic fungi, particularly Nocardia species. As many as 30% of cases of nocardiosis may show cerebral involvement.

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