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March 1974

The Brain in Unclassified Mental Retardation.

Arch Neurol. 1974;30(3):272. doi:10.1001/archneur.1974.00490330080017

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This is the report of a study group held under the auspices of the Ciba Foundation, London. The large and vexingly elusive problem of the causes and possible treatments for undifferentiated mental retardation is considered from a variety of clinical and experimental standpoints. As Jellinger, the pathologist, said in remarking that 90% of his series showed organic changes in the brain at autopsy, "What was once an almost uniform entity, 'mental retardation,' has been fragmented under the incessant scrutiny of biological science into a veritable mosaic of etiologically distinct conditions." While it is true that the percentage of specific morphologic abnormalities declines in children with less severe retardation surviving to a later age, the studies in this volume indicate how much has already been contributed by persistent, patient research. Individual chapters consider clinical and experimental evidence bearing on the influence of hormones on brain development, changes in enzyme activity during

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