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April 1974

Reye Syndnrome: An Association With Type 1 Vaccine-like Poliovirus

Author Affiliations

Iowa City
From the departments of pediatrics and neurology, University Hospitals, University of Iowa College of Medicine, Iowa City.

Arch Neurol. 1974;30(4):304-306. doi:10.1001/archneur.1974.00490340032006

Polio type 1 vaccine-like virus was isolated from spinal fluid, ileum, and brain tissue of a 7-year-old girl whose clinical course and postmortem findings were typical of Reye syndrome. History revealed previous immunization with seven courses of inactivated polio vaccine and close contact, three weeks before her illness, with a child recently immunized with oral trivalent attenuated poliovirus.

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