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April 1974

Parainfluenza, Histocompatibility, and Multiple Sclerosis: Association of Parainfluenza Antibodies and Histocompatibility Types in MS and Optic Neuritis

Author Affiliations

From the Department of Neurology (Drs. Lehrich, Arnason, and Wray) and the MGH Transplantation Unit, Department of Surgery (Dr. Fuller), Massachusetts General Hospital, and Harvard Medical School, Boston.

Arch Neurol. 1974;30(4):327-329. doi:10.1001/archneur.1974.00490340055013

Serum hemagglutination-inhibition (HI) antibodies to parainfluenza type 1 virus and histocompatibility types were determined in 46 multiple sclerosis (MS) patients, 20 optic neuritis patients, and 54 control subjects. No significant differences in antibody titers were found when the MS, optic neuritis, and control groups were compared, nor when subjects bearing the HL-A3 histocompatibility antigen were compared with non-HL-A3 bearers. A significantly increased frequency of HLA3 was found among MS patients (42.9%) as compared with controls (23.0%) and optic neuritis patients (20.0%).

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