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May 1974

Unilateral Pupillary Dilatation During Adversive Seizures

Author Affiliations

From the departments of neurology (Drs. Zee, Griffin, and Price) and pathology (Dr. Price), Johns Hopkins University School of Medicine, Baltimore.

Arch Neurol. 1974;30(5):403-405. doi:10.1001/archneur.1974.00490350061010

A patient had adversive seizures accompanied by unilateral pupillary dilatation. Neuropathologic examination showed a contusion involving the middle frontal gyrus contralateral to the pupil that dilated during the seizure. The clinical features and the location of this lesion (presumably the epileptogenic focus) correlate well with experimental studies in which pupillary changes have been observed during stimulation of the cerebral cortex. Unilateral mydriasis associated with contraversion of the eyes during seizures may have value in localizing epileptogenic foci.

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