Distributions of pertechnetate, albumin, sodium, and antipyrine in cat brains were studied four hours to 20 days after occlusion of one middle cerebral artery (MCA). Brain:blood ratios for each substance were greatest in infarcted tissue and least in nonischemic tissue. Higher ratios for pertechnetate than for albumin in nonischemic tissue indicated a normal extravascular distribution of pertechnetate. In ischemic and infarcted tissue, brain:blood ratios for pertechnetate, albumin, and sodium were increased as early as four hours after MCA occlusion, were maximal at four to seven days, and remained high (for pertechnetate) until 20 days. Distributions of water after MCA occlusion did not have the same temporal or spatial characteristics as distributions of the other substances; thus, ischemic cerebral edema is not related solely to disruptions of the blood-brain barrier or to extravascular accumulations of sodium and protein.
O'Brien MD, Jordan MM, Waltz AG. Ischemic Cerebral Edema and the Blood-Brain Barrier: Distributions of Pertechnetate, Albumin, Sodium, and Antipyrine in Brains of Cats After Occlusion of the Middle Cerebral Artery. Arch Neurol. 1974;30(6):461–465. doi:10.1001/archneur.1974.00490360037008
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: