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September 1974

Adreno-leukodystrophy (Sex-Linked Schilder Disease)Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System

Arch Neurol. 1974;31(3):210-213. doi:10.1001/archneur.1974.00490390092013

An ultrastructural study of the central nervous system of four male patients with adreno-leukodystrophy has been performed. Membrane-like cytoplasmic inclusions similar to those described in adrenal cortex, testis, and peripheral nerve were present in macrophages. These changes in widely scattered organs are probably the structural representation of a generalized metabolic disorder and are consistent with our previous hypothesis of a membrane-stability defect in these organs.