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October 1974

Influenza Virus Antigen in Postencephalitic Parkinsonism Brain: Detection by Immunofluorescence

Author Affiliations

From the departments of neurology (Drs. Gamboa, Yahr, and Harter), microbiology, and pathology (Drs. Wolf, Duffy, Barden, and Hsu), College of Physicians and Surgeons, Columbia University, New York. Dr. Yahr is now with the Department of Neurology, Mount Sinai Medical Center, New York.

Arch Neurol. 1974;31(4):228-232. doi:10.1001/archneur.1974.00490400042003

Brains of six patients with postencephalitic parkinsonism were examined for influenza virus antigen by direct immunofluorescence. Tissue sections were exposed to fluorescein-conjugated globulin directed against the NWS, WSN, WS, and PR8 strains of influenza A0, the ribonucleoprotein of the WSN strain, the swine strain of influenza A, the Japan strain of influenza A2, the Lee strain of influenza B, measles, and herpes simplex virus.

Intranuclear fluorescent antigen was detected in hypothalamic and midbrain sections prepared from all six cases after staining with antibody to the two neurotropic influenza A0 strains (NWS and WSN) and to the ribonucleoprotein of the WSN strain.

No fluorescence was observed after staining of similar sections prepared from the brains of five patients with idiopathic Parkinson disease with labeled influenza NSW antiserum.