A 22-month-old hyperuricosuric patient had a progressive central nervous system syndrome that initially was manifested as a seizure disorder associated with a normal electroencephalogram. By 8 years of age, the boy's EEG had become severely abnormal, he was thought to be "mentally retarded," and his seizure disorder could not be controlled by classic anticonvulsant therapy. Oral administration of allopurinol with concomitant decrease in dose of other anticonvulsants was accompanied by control of the patient's seizures, reversal of his EEG back into the normal range, and a striking improvement In his ability to learn.
Coleman M, Landgrebe M, Landgrebe A. Progressive Seizures With Hyperuricosuria Reversed by Allopurinol. Arch Neurol. 1974;31(4):238–242. doi:10.1001/archneur.1974.00490400052005
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