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October 1974

Diphenylhydantoin and Calcium Movement in Lobster Nerves

Author Affiliations

From the Department of Neurology, Yale University School of Medicine, New Haven, Conn. Part of this work was done by Dr. Hasbani in partial fulfillment of the requirement for the degree of Doctor of Medicine from Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Arch Neurol. 1974;31(4):250-254. doi:10.1001/archneur.1974.00490400064007

Diphenylhydantoin reduces calcium Ca 45 uptake and outflow in resting lobster axons and eliminates the increase in 45Ca accumulation that normally occurs during stimulation. Hydroxyphenyl-phenylhydantoin was found to be without effect on resting or stimulated nerves with respect to 45Ca uptake. Procaine hydrochloride shared the same effects as diphenylhydantoin on resting nerves. It is hypothesized that a major mechanism of action of diphenylhydantoin is similar to that of local anesthetics.

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