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November 1974

p-Nitrophenylphosphatase in Denervated Muscle

Author Affiliations

From the Division of Neurology, Duke University Medical Center, Durham, NC.

Arch Neurol. 1974;31(5):317-319. doi:10.1001/archneur.1974.00490410065006

Denervation of the rat hind limb was found to increase the K+-independent p-nitrophenylphosphatase (basic pNPPase) activity of the isolated sarcolemma. There was no change in K+-stimulated p-NPPase and Na+, K+-stimulated adenosine triphosphatase. This increased enzyme activity might underlie the postspike increase in K+ conductance of denervated sarcolemma in view of the proposal that basic p-NPPase activity is related to the rate of passive flux of K+.

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