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January 1975

Mouse Hepatitis Virus-Induced Recurrent Demyelination: A Preliminary Report

Author Affiliations

From the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore.

Arch Neurol. 1975;32(1):32-35. doi:10.1001/archneur.1975.00490430054008

Four-week-old BALB/c mice inoculated intracerebrally with the JHM strain of mouse hepatitis virus developed an acute demyelinating disease followed by apparent recovery with remyelination. When surviving mice were examined 16 months later, small areas of active demyelination were still present. This is the first reported example, to our knowledge, of an experimental viral infection in which acute demyelination with recovery is followed by persisting or recurring demyelination.

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