Since first described by Negri in 1903, the Negri body has been regarded as a pathognomonic finding in signifying the presence of rabies encephalitis. Negri bodies (light microscope) were found in the brain of a patient with conclusive evidence against the presence of rabies encephalitis. This case provided the opportunity for a pertinent review of the literature In bringing the subject into a reasoned perspective. A definitive etiologic diagnosis of rabies requires the use of electron microscopical or immunofluorescent methods or both.
Derakhshan I. Is the Negri Body Specific for Rabies?A Light and Electron Microscopical Study. Arch Neurol. 1975;32(2):75–79. doi:10.1001/archneur.1975.00490440025002
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