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February 1975

Is the Negri Body Specific for Rabies?A Light and Electron Microscopical Study

Arch Neurol. 1975;32(2):75-79. doi:10.1001/archneur.1975.00490440025002

Since first described by Negri in 1903, the Negri body has been regarded as a pathognomonic finding in signifying the presence of rabies encephalitis. Negri bodies (light microscope) were found in the brain of a patient with conclusive evidence against the presence of rabies encephalitis. This case provided the opportunity for a pertinent review of the literature In bringing the subject into a reasoned perspective. A definitive etiologic diagnosis of rabies requires the use of electron microscopical or immunofluorescent methods or both.