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February 1975

Response of Serum Creatine Phosphokinase to Steroid Hormone: Prednisolone Test for Muscle Diseases

Author Affiliations

From the Third Department (Drs. Takahashi, Takai, and Imura) and the Second Department (Drs. Oimomi and Shinko) of Internal Medicine, Kobe University School of Medicine, Kobe, and Hyogo Chuo Hospital (Drs. Shutta and Matsuo), Sanda City, Hyogo Pref., Japan.

Arch Neurol. 1975;32(2):89-91. doi:10.1001/archneur.1975.00490440039005

Serum creatine phosphokinase activity increased significantly four or six hours after the administration of prednisolone in patients with muscular dystrophy of various types, whereas it did not increase in other muscular disorders. The extent of the response correlated inversely with the grade of disability. The prednisolone test may help to differentiate muscular dystrophy from polymyositis.

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