A light microscopic study was performed during the preictal period following the administration of methionine sulfoximine (MSO) to adult rats. The principal morphologic observation was the development of Alzheimer II astrocytes in gray matter, suggesting that the metabolic abnormality induced by MSO is initially confined to the astrocyte. In view of the association of the Alzheimer II astrocyte with hyperammonemic states, the drug toxicity may be secondary to the presence of ammonia. A possible mechanism involves astrocytes in the development of seizures produced by MSO.
Gutierrez JA, Norenberg MD. Alzheimer II Astrocytosis Following Methionine Sulfoximine. Arch Neurol. 1975;32(2):123–126. doi:10.1001/archneur.1975.00490440073012
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: