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February 1975

Clonidine in Parkinson Disease

Author Affiliations

From the University Department of Neurology, Institute of Psychiatry and King's College Hospital, London; the Department of Neurology, Boston University School of Medicine; and Neurology Service, Veterans Administration Hospital, Boston.

Arch Neurol. 1975;32(2):134-136. doi:10.1001/archneur.1975.00490440084016

Several theoretical considerations suggest that potentiation of central norepinephrine mechanisms may improve motor performance in patients with Parkinson disease receiving concurrent treatment with levodopa. Clonidine hydrochloride, an antihypertensive drug believed to directly stimulate brain norepinephrine receptors, was administered to a group of patients with relatively mild Parkinson disease and coexisting essential hypertension and to three patients with Parkinson disease manifesting the "on-off" response to levodopa. Although a significant antihypertensive effect was achieved, a change in parkinsonian disability could not be demonstrated.

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