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March 1975

Two Cases of Acute Pandysautonomia

Author Affiliations

From the Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan.

Arch Neurol. 1975;32(3):146-151. doi:10.1001/archneur.1975.00490450026002

Two men had acute nonprogressive pandysautonomia. Both of them showed orthostatic hypotension, fainting in upright position, pupillary disturbances, diminished sweating, anacidity, and impotence. Case 1 showed considerable but inadequate improvement within 31 months. Case 2 recovered completely after 11 months.

Clinical and pharmacodynamic investigations suggested that the main lesion was located in postganglionic fibers in case 1 and in preganglionic fibers in case 2. The cause of this disorder is unknown, although both patients had undergone substantial weight loss.

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