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April 1975

Mechanism of Colistin-Induced Neuromuscular Depression

Author Affiliations

From the Institute of Neurophysiology, University of Copenhagen, Denmark.

Arch Neurol. 1975;32(4):235-238. doi:10.1001/archneur.1975.00490460051006

The effect of a high concentration of the antibiotic colistin sulfate on neuromuscular transmission was examined by recording intracellularly from rat diaphragm blocked with tubocurarine chloride. The presynaptic effect of colistin was different from that of neomycin sulfate, which reduces the probability of acetylcholine release: Colistin reduced the quantum content of the initial and the last 20 end-plate potentials of a train of 40 stimuli without altering the probability of acetylcholine release. The quantum size was reduced, while the frequency of miniature end-plate potentials was unchanged.

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